True
PDRN – A Powerful Skin Regeneration Booster

Polydeoxyribonucleotide (PDRN) therapy has become one of the most promising innovations in aesthetic medicine for skin rejuvenation and repair. Extracted from salmon DNA, PDRN is renowned for its ability to stimulate cell growth, accelerate tissue repair, and improve skin texture. In recent years, it has gained popularity among dermatologists and aesthetic practitioners as a safe, effective, and scientifically backed treatment for various skin concerns, from photoaging to scars.

In this article, we will explore what PDRN is, how it works, its types, key effects on the skin, and why it is considered a powerful anti-aging solution.


What Is PDRN?

PDRN stands for polydeoxyribonucleotide, a DNA fragment derived from the sperm cells of salmon. It is highly biocompatible with human skin and recognized for its regenerative and anti-inflammatory properties.

In aesthetic medicine, PDRN is used in mesotherapy, biorevitalization, and post-procedure recovery protocols. Its unique ability to stimulate fibroblast activity and enhance vascularization makes it a key ingredient in treatments aimed at restoring skin health [1].

At Cosmo Korea, some of the most popular PDRN-based products include Kiara Reju, Soonsu Ultra Reju, and Rejuran Healer, all known for their exceptional skin-repairing properties.


How Does PDRN Work?

PDRN works by stimulating adenosine A2 receptors in skin cells, which activates key regenerative processes [2]. Once injected into the dermis, PDRN triggers:

  • Fibroblast activation – boosts collagen and elastin production.

  • Angiogenesis stimulation – promotes the formation of new capillaries, improving oxygen and nutrient supply.

  • Anti-inflammatory action – reduces redness, swelling, and irritation.

  • DNA repair support – helps damaged cells recover faster.

This mechanism leads to visible improvements in skin elasticity, hydration, and tone. PDRN also shortens downtime after aggressive procedures like fractional CO₂ laser or chemical peels.


Types of PDRN Treatments

1. Injectable PDRN

2. Topical PDRN

  • Creams and serums with PDRN for at-home maintenance.

  • Best for hydration and barrier repair.

3. Combination Protocols

  • Often used with microneedling, RF therapy, or hyaluronic acid.

  • Enhances penetration and prolongs results.

  • Example: pairing Ultra Reju with microneedling for enhanced skin renewal.

Advantages of PDRN Therapy

  • Intensive regeneration – accelerates skin healing and renewal.

  • Hydration boost – provides deep moisture and helps maintain the skin’s hydro balance.

  • Anti-aging action – smooths fine lines and improves elasticity.

  • Safe and well-tolerated – minimal risk of allergic reactions.

  • Versatile use – effective for face, neck, décolleté, and hands.

Studies confirm that PDRN significantly improves skin texture, reduces pigmentation, and increases dermal thickness after just a few sessions [1][3]. Many of these benefits can be achieved with professional products like Rejuran Healer or Kiara Reju.


Who Should Consider PDRN Therapy?

PDRN therapy is recommended for individuals who:

  • Show early or moderate signs of skin aging.

  • Have dull, dehydrated skin.

  • Are recovering from laser, peeling, or RF treatments.

  • Have scars or post-acne marks.

  • Want to improve skin elasticity and tone without fillers.

Patients looking for professional-grade results often choose in-clinic procedures with Kiara Reju or Ultra Reju.


PDRN therapy represents a breakthrough in skin regeneration and anti-aging treatments. By boosting collagen production, enhancing microcirculation, and repairing damaged DNA, it delivers visible, long-lasting results with minimal downtime. Whether used alone or in combination with other aesthetic procedures, PDRN offers a safe and highly effective way to restore skin health and beauty.


References

1. Marques C, Porcello A, Cerrano M, Hadjab F, Chemali M, Lourenço K, Hadjab B, Raffoul W, Applegate LA, Laurent AE. From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules. Int J Mol Sci. 2024. PMID: 39858543; PMCID: PMC11764130.

2. Oh N, Hwang J, Kang MS, Yoo CY, Kwak M, Han DW. Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration. Biomater Res. 2025 Apr 14;29:0183. doi:10.34133/bmr.0183. PMID: 40231205; PMCID: PMC11994882.

3. Jang SK, Choi J, Lim HW, Kim HG, Yoo YM. Comparative Analysis of Melatonin and Polydeoxyribonucleotide: Possible Benefits of Co-Treatment Effects and Potential Synergistic Applicability. Int J Mol Sci. 2025 Jun 13;26(12):5703. doi:10.3390/ijms26125703. PMID: 40565167; PMCID: PMC12193528.


Exosomes in Aesthetic Medicine: A Revolution in Skin Rejuvenation